Published: Sat, January 26, 2019
Sci-tech | By Patricia Wade

Biomedical Research: Scientists clone five gene-edited monkeys

Biomedical Research: Scientists clone five gene-edited monkeys

Scientists have successfully cloned five genetically-altered baby monkeys for very first time.

Macaques are chiefly Asian monkeys typically having a sturdy build and including some short-tailed or tailless forms.

Chinese scientists say the advance, reported online by the journal National Science Review, shows that a population of "customised" gene-edited macaque monkeys with uniform genetic background will soon be available for biomedical research.

This latest experiment took place at China's new brain science research park, launched past year in Shanghai by the Chinese Academy of Sciences's Institute of Neuroscience and local government.

After the new experiment, five infant macaques born at the Chinese Academy of Sciences' Institute of Neuroscience in Shanghai all share the exact same genes, derived from a fibroblast taken from the skin of a donor monkey.

To create an ideal donor monkey, the researchers knocked out BMAL1, a core circadian regulatory transcription factor, using gene editing at the embryo stage.

The investigation found that he and his team had edited the genes of human embryos and then implanted the embryos in female volunteers, as he claimed past year.

The scientist deliberately evaded regulation and supervision, raised his own funds and employed his own team for the gene-editing project on human embryos in "pursuit of personal fame and benefit", according to Xinhua, citing the probe.

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"Our approach is to ... select one monkey that exhibits the correct gene-editing and most severe disease phenotypes as the donor monkey for cloning", Sun Qiang, the scientist who led the study, said in a press statement.

After Chinese scientists due to their Gene - and clone-were experiments, highlighted the state Agency that the research programme had been monitored by the ethics Committee of the Institute "in Accordance with global Standards for animal research".

"Some of them will carry gene mutations known to cause human brain disorders, in order to generate useful monkey models for drug development and treatment".

There is oft-used Chinese idiom that describes how every the Chinese government, from the dynasties to the Communist Party, doles out punishment to ward off subsequent offenders: Kill the chicken to scare the monkey. Using the gene-editing tool CRISPR/Cas9, He removed a gene linked to HIV.

Despite the excitement in the biomedical field, China's cloned monkeys sparked concerns among animal welfare groups across the world.

The second deals with the cloning of said gene-edited monkey.

The scientists planned to improve the cloning technique to make it more efficient. "This line of research will help to reduce the amount of macaque monkeys now used in biomedical research around the world". It is the same method, with the help of 2017, the first clone monkeys, Zhong Zhong, and Hua Hua had arisen - some 22 years after the birth of clone sheep Dolly.

ION, CAS is following strict worldwide guidelines for animal research. Many researchers anxious authorities might overlook He's infractions.

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